Pathogenesis and Treatment of Systemic Sclerosis
نویسندگان
چکیده
منابع مشابه
[Systemic sclerosis--pathogenesis, clinical manifestations and treatment].
Diffuse systemic sclerosis (SSc) is a chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin and internal organs. Pathogenesis of SSc involves immunologic mechanisms, vascular damage and activation of fibroblasts. SSc varies in severity and progression; most patients eventually develop visceral complications, which are the usual causes of death...
متن کاملPathogenesis of Systemic Sclerosis
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities leading to production of autoantibodies and...
متن کاملPathogenesis of scleroderma (systemic sclerosis).
Increasing interest in the vascular features of scleroderma has led to the hypothesis that the blood vessel is the major target tissue and that the endothelial cell is the principal cell target. Useful observations stemming from the vascular hypothesis include the use of microvascular abnormalities in the early detection of the patient destined to develop classical scleroderma, the discovery of...
متن کاملOverview of pathogenesis of systemic sclerosis.
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the development of this disease remain unclear. The pathogenesis is known to involve endothelium, epithelium, fibroblasts, innate and adaptive immune systems and their component immunological mediators. Endothelial cell damage may be the initiating factor, but the precise triggering event(s) remain elusive....
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2013
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.102.1226